검색
검색 팝업 닫기

Ex) Article Title, Author, Keywords

Article

review

Pharmacoepidemiology and Risk Management 2024; 16(2): 91-99

Published online September 30, 2024 https://doi.org/10.56142/perm.24.0011

Copyright © Korean Society for Pharmacoepidemiology and Risk Management.

Drug Induced Hyponatremia in the Elderly

노인에서 발생하는 약물에 의한 저나트륨혈증

Young Rim Song1,2

송영림1,2

1Division of Nephrology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea
2Hallym University Kidney Research Institute, Chuncheon, Korea

1한림대성심병원 신장내과, 2한림대학교 신장연구소

Correspondence to:Young Rim Song
Division of Nephrology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170 beon-gil, Dongan-gu, Anyang 14068, Korea
Tel: +82-31-380-3720
Fax: +82-31-380-1669
E-mail: yrisong@hanmail.net

Received: March 12, 2024; Revised: April 23, 2024; Accepted: May 22, 2024

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hyponatremia is the most common electrolyte imbalance and usually induced by renal water retention due to the presence of factors contributing to increased antidiuretic hormone, low glomerular filtration rate and poor intake of salt and protein in the elderly population. Although symptom severity varies according to the severity, duration and rapidity of hyponatremia, mild chronic hyponatremia is associated with frailty, osteoporosis, cognitive impairment and gait disturbance. The syndrome of inappropriate antidiuretic hormone secretion and endocrinopathies such as hypothyroidism and adrenal insufficiency are major causes of hyponatremia, but medications have been considered as an important factor of water imbalance, and thiazide diuretics, psychotropic agents, anticancer chemotherapeutic drugs and vasopressin analogues are major hyponatremia-inducing drugs in clinical practice. Syndrome of inappropriate anti-diuresis (SIAD) is a main pathogenesis of drug-induced hyponatremia, but multifactorial factors are associated with hyponatremia in old patients. Clinicians should prescribe these potential drugs with caution, especially in those with risk factors for SIAD. The treatment of hyponatremia depends on the severity and type of hyponatremia, and all offending drugs should be discontinued and re-administration of these drugs is strongly discouraged.

KeywordsSodium, Hyponatremia, Adverse drug reaction, Elderly, Syndrome of inappropriate anti-diuresis

Korean Society for Pharmacoepidemiology and Risk Management

Vol.16 No.2
September, 2024

eISSN 2982-5954

Frequency: Bimonthly

Current Issue   |   Archives

Stats or Metrics

Share this article on :

  • line